TILT Biotherapeutics.
نویسنده
چکیده
منابع مشابه
Recent Advances in Biotherapeutics Drug Discovery and Development
Biotherapeutics drugs, such as antibodies, Fc-like fusion proteins, and therapeutic replacement enzymes, constitute the most rapidly growing drug class, and have become a major clinical success of human therapeutics over the past decade. These therapeutics of large-molecule have revolutionized the treatment of a variety of diseases in areas such as oncology, inflammatory and autoimmune diseases...
متن کاملGut microbiota: next frontier in understanding human health and development of biotherapeutics
The gut microbiota is a remarkable asset for human health. As a key element in the development and prevention of specific diseases, its study has yielded a new field of promising biotherapeutics. This review provides comprehensive and updated knowledge of the human gut microbiota, its implications in health and disease, and the potentials and limitations of its modification by currently availab...
متن کاملDmd058917 1858..1866
Remarkable methodological advances in the past decade have expanded the application of liquid chromatography coupled with mass spectrometry (LC/MS) analysis of biotherapeutics. Currently, LC/MS represents a promising alternative or supplement to the traditional ligand binding assay (LBA) in the pharmacokinetic, pharmacodynamic, and toxicokinetic studies of protein drugs, owing to the rapid and ...
متن کاملBiotransformation and in vivo stability of protein biotherapeutics: impact on candidate selection and pharmacokinetic profiling.
Historically, since the metabolism of administered peptide/protein drugs ("biotherapeutics") has been expected to undergo predictable pathways similar to endogenous proteins, comprehensive biotherapeutic metabolism studies have not been widely reported in the literature. However, since biotherapeutics have rapidly evolved into an impressive array of eclectic modalities, there has been a shift t...
متن کاملPolysorbates, peroxides, protein aggregation, and immuno- genicity – a growing concern
Aggregation can have a number of deleterious effects on biotherapeutics including the loss of efficacy, the induction of unwanted immunogenicity, altered pharmacokinetics, and reduced shelf life. Aggregation is ameliorated by the inclusion of surfactants in biotherapeutics formulations, typically non-ionic polymeric ether surfactants. The most commonly used examples are Tween 20 (Polysorbate 20...
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عنوان ژورنال:
- Human vaccines & immunotherapeutics
دوره 13 5 شماره
صفحات -
تاریخ انتشار 2017